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    LH031




















    LH031是一种新靶点的抗肿瘤小分子药物。是一种EG5抑制剂,通过抑制EG5从而抑制肿瘤细胞的有丝分裂。是属于微管类药物的新一代品种(第一代品种为紫杉醇),效果优于紫杉醇类,且为靶向药物,不具有细胞毒性。有望广泛应用于多种实体肿瘤,以及血液/淋巴癌。目前在患者的临床试验中已有效果的体现。2018年已取得国内临床批件。



    已发表文献:

    [1] Jordan, M.A.; Wilson, L. Microtubules as a target for anticancer drugs. Nature Reviews Cancer 2004, 4, 253-265

    [2] Miyamoto, D.T.; Perlman, Z.E.; Mitchison, T.G.; Shirasu-Hiza, M. Dynamics of the mitotic spindle – potential therapeutic targets. Prog. Cell Cycle Res. 2003, 5, 349- 360

    [3] Ivachtchenko, A.V.; Kiselyov, A.S.; Tkachenko, S.E.; Ivanenkov, Y.A.; Balakin, K.V. Novel mitotic targets and their small-molecule inhibitors. Curr Cancer Drug Targets 2007, 7, 766-784

    [4] Cavalletti, G.; Cavalletti, E.; Montaguti, P.; Oggioni, N.; De Negri, O.; Tredici, G. Effect on the peripheral nervous system of the short-term intravenous administration of paclitaxel in the rat. Neurotoxicology 1997, 18, 137-145

    [5] Wood, K.W.; Cornwell, W.D.; Jackson J.R. Past and future of the mitotic spindle as an oncology target. Curr Opin Pharmacol 2001, 1, 370-377

    [6] Miki, H.; Okada, Y.; Hirokawa, N. Analysis of the kinesin superfamily : Insights into structure and function. Trends Cell Biol 2005, 15, 467-476

    [7] Huszar, D.; Theoclitou, M.E.; Skolnik, J.; Herbst, R. Kinesin motor proteins as targets for cancer therapy. Cancer Metastasis Rev 2009, 28, 197-208

    [8] Cape PA et al. A simple recording grip strength device; Pharmacology, biochemistry, and behaviour 1978, Vol. 8, p101-102

    [9] Löscher W et al. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs III. Pentylenetetrazole seizure models; Epilepsy research 1991, Vol. 8, 171-189

    [10] Pulewka P. Das Auge der Maus als Pharmakologisches Test-Objekt; Nauny Schmiedeberg’s Arch Exp Path Pharm 1932, Vol 168, 307-318

    [11] Friedman MHF, Animal techniques for evaluating laxatives in Animal and Clinical Pharmacological Techniques in Drug Evaluation’, Nodine JH and Siegler PE (eds.), Yearbook Medical Publishers Inc, Chicago, 480-486, 1964

    [12] Komlodi-Pasztor E, Sackett D, Wilkerson J, Fojo T. Mitosis is not a key target of microtubule agents in patients tumors. Nature Reviews Clinical Oncology 2011, 8, 244- 250

    [13] Rath O. & Kozielski F. Kinesins and Cancer. Nature Reviews in Cancer 2012, 12, 527-539

     


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